Sjögren's Syndrome

Recommendations and Guidelines

EULAR recommendations for the management of Sjögren’s syndrome with topical and systemic therapies                                                                                                                          ( Ann Rheum Dis 2020 Jan;79(1):3-18. )

Treatment of primary Sjögren syndrome
(Nat Rev Rheumatol  2016;12:456–471)

Criteria and Outcome Measures

Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group
(Ann Rheum Dis 2002;61:554-58)

American College of Rheumatology Classification Criteria for Sjögren’s Syndrome: A Data-Driven, Expert Consensus Approach in the SICCA Cohort
(Arthritis Care Res (Hoboken) 2012; 64(4): 475–487)

2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome. A consensus and data-driven methodology involving three international patient cohorts
(Ann Rheum Dis Published Online First: 26 October 2016 doi:10.1136/annrheumdis-2016-210571)

Outcome measures for primary Sjögren's syndrome: A comprehensive review
(J Autoimmun 2014;51:51-56)

Disease Scores and Online Calculators

EULAR Sjogren’s syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjogren’s syndrome.
(Ann Rheum Dis 2010;69:1103–9)

EULAR Sjogren’s Syndrome Patient Reported Index (ESSPRI): development of a consensus patient index for primary Sjogren’s syndrome.
(Ann Rheum Dis 2011;70:968–72)

Development of the ClinESSDAI: a clinical score without biological domain. A tool for biological studies.
(Ann Rheum Dis 2016 doi: 10.1136/annrheumdis-2015-208504)

Scales and Questionnaires

Impact of dry eye on everyday life (IDEEL) questionnaire
(Health Qual Life Outcomes 2011;9:111)

The Sjögren’s Syndrome Damage Index
(Rheumatology (Oxford) 2008;47:1193-8)

Development of the Sjögren's Syndrome Responder Index, a data-driven composite endpoint for assessing treatment efficacy.
(Rheumatology (Oxford). 2015 Sep;54(9):1699-708)

Imaging Tools

Is salivary gland ultrasonography a useful tool in Sjögren's syndrome? A systematic review.
(Rheumatology (Oxford) 2016;55(5):789-800)

Can ARFI elastometry of the salivary glands contribute to the diagnosis of Sjögren's syndrome?
(Joint Bone Spine 2016;83(3):301-6)


Sjögren syndrome. (Nat Rev Dis Primers 2016;2:16047)

A review of salivary gland histopathology in primary Sjögren's syndrome with a focus on its potential as a clinical trials biomarker.
(Ann Rheum Dis. 2015;74(9):1645-50)

United Kingdom Primary Sjögren's Syndrome Registry (UKPSSR)