What Is New - Systemic Lupus Erythematosus and Connective Tissue Diseases

Take a look at our 'What is new' highlights in systemic lupus erythematosus and connective tissue diseases!

September 2022

" Interleukin-13 Receptor α1-Mediated Signaling Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis"

Why WIN?

IL-13 receptor α1 (IL-13Rα1) which is an X-linked receptor that transmits IL-4/IL-13 signals, is seemed affecting regulation of Age-associated/autoimmune B cells (ABCs) through interleukin-21 (IL-21) signalling and its interplay with interferon-γ and IL-4. Human researchs may be conducted on this pathway to investigate sex differeneces in SLE and the data can translate into a potential target for new drug discoveries in the future.

Interactive question

Can IL-13Rα1 and related signalling pathway be one of the factors to explain sex differences in SLE? Furthermore, can it be potential target for SLE through ABCs?

Yes / No

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"Changes on chest HRCT in systemic sclerosis-related interstitial lung disease after autologous hematopoietic stem cell transplantation"

Why WIN?

This study evaluates chest HRCT, lung function and skin score in SSc patients after haematopoietic stem cell transplantation (aHSCT), showing a significant improvement in extent of ILD 24 months after aHSCT, whilst esophageal dilatation and volume worsened. 78% of SSc patients reached radiological response 24 months after aHSCT. This study offers real-world data about the use of aHSCT in early SSc.

Interactive question

What is your experience with haematopoietic stem cell transplantation in systemic sclerosis?

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May 2022

"Proteogenomic analysis of the autoreactive B cell repertoire in blood and tissues of patients with Sjögren's syndrome"

Why WIN?

This omic data illuminated affinity maturation related ANA and RF repertoires findings for the molecular mechanisms of autoreactivity, lymphomagenesis and rituximab response in SjS.

Interactive question

Are novel potential biomarkers derived from this proteomic data promising to be introduced in routinely clinical practice for prediction lymphomagenesis in SjS patients?

Agree / Disagree

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"Impact of Distinct Therapies on Antibody Response to SARS-CoV-2 Vaccine in Systemic Lupus Erythematosus"

Why WIN?

The impact of immunosuppressive drugs on immunogenicity of SARS-CoV-2 vaccine has been one of the main concerns in the management of SLE patients during the pandemic. In this study, the analysis of individual drug effect showed improved seroconversion in HCQ monotherapy, while MMF and prednisone were associated with a lower vaccine response in SLE patients compared to controls.

Interactive question

Have you considered temporary withdrawal of MMF prior to SARS-CoV-2 vaccine in SLE patients?

yes/no

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