What Is New - Systemic Lupus Erythematosus and Connective Tissue Diseases

Take a look at our 'What is new' highlights in systemic lupus erythematosus and connective tissue diseases!

September 2022

" Interleukin-13 Receptor α1-Mediated Signaling Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis"

Why WIN?

IL-13 receptor α1 (IL-13Rα1) which is an X-linked receptor that transmits IL-4/IL-13 signals, is seemed affecting regulation of Age-associated/autoimmune B cells (ABCs) through interleukin-21 (IL-21) signalling and its interplay with interferon-γ and IL-4. Human researchs may be conducted on this pathway to investigate sex differeneces in SLE and the data can translate into a potential target for new drug discoveries in the future.

Interactive question

Can IL-13Rα1 and related signalling pathway be one of the factors to explain sex differences in SLE? Furthermore, can it be potential target for SLE through ABCs?

Yes / No

Share your response with us using the hashtag #WhatIsNew and tag us @EMEUNET

"Changes on chest HRCT in systemic sclerosis-related interstitial lung disease after autologous hematopoietic stem cell transplantation"

Why WIN?

This study evaluates chest HRCT, lung function and skin score in SSc patients after haematopoietic stem cell transplantation (aHSCT), showing a significant improvement in extent of ILD 24 months after aHSCT, whilst esophageal dilatation and volume worsened. 78% of SSc patients reached radiological response 24 months after aHSCT. This study offers real-world data about the use of aHSCT in early SSc.

Interactive question

What is your experience with haematopoietic stem cell transplantation in systemic sclerosis?

Share your response with us using the hashtag #WhatIsNew and tag us @EMEUNET

May 2022

"Proteogenomic analysis of the autoreactive B cell repertoire in blood and tissues of patients with Sjögren's syndrome"

Why WIN?

This omic data illuminated affinity maturation related ANA and RF repertoires findings for the molecular mechanisms of autoreactivity, lymphomagenesis and rituximab response in SjS.

Interactive question

Are novel potential biomarkers derived from this proteomic data promising to be introduced in routinely clinical practice for prediction lymphomagenesis in SjS patients?

Agree / Disagree

Join the discussion on twitter... Share your response with us using the hastag  #WhatIsNew and tag us @EMEUNET

 

"Impact of Distinct Therapies on Antibody Response to SARS-CoV-2 Vaccine in Systemic Lupus Erythematosus"

Why WIN?

The impact of immunosuppressive drugs on immunogenicity of SARS-CoV-2 vaccine has been one of the main concerns in the management of SLE patients during the pandemic. In this study, the analysis of individual drug effect showed improved seroconversion in HCQ monotherapy, while MMF and prednisone were associated with a lower vaccine response in SLE patients compared to controls.

Interactive question

Have you considered temporary withdrawal of MMF prior to SARS-CoV-2 vaccine in SLE patients?

yes/no

Join the discussion on twitter... Share your response with us using the hastag  #WhatIsNew and tag us @EMEUNET

 

April 2022

March 2022

November 2021

October 2021

January 2021

December 2020

November 2020

October 2020

September 2020

February 2020

January 2020

December 2019

November 2019

September 2019

August 2019

July 2019

June 2019

May 2019

April 2019

March 2019

February 2019

January 2019

December 2018

November 2018

October 2018

September 2018

Click here to be directed to the article by Doria et al (2018).

Click here to be directed to the article by Putterman et al (2018).

August 2018

Click here to be directed to the article by Recke et al (2018).

Click here to be directed to the article by Romano et al (2018).

July 2018

Click here to be directed to the article by Sciasca et al (2018).

Click here to be directed to the article by Toro-Dominguez et al (2018).

June 2018

Click here to be directed to the article by Birnbaum et al (2018).

Click here to be directed to the article by Ulff-Møller et al (2018).

May 2018

Click here to be directed to the article by Rodríguez-Pintó et al (2018).

Click here to be directed to the article by Imgenberg-Kreuz et al (2018).

April 2018

Click here to be directed to the article by Herrick et al (2018).

Click here to be directed to the article by Greiling et al (2018).

March 2018

Click here to be directed to the article by Zhang et al (2018).

Click here to be directed to the article by Taher et al (2018).

February 2018

Click here to be directed to the article by Barbhaiya et al (2018).

Click here to be directed to the article by Kim et al (2018).

January 2018

Click here to be directed to the article by Sanchez et al (2017).

Click here to be directed to the article by Ekinci et al (2017).

December 2017

Click here to be directed to the article by Tjarnlund et al (2017).

Click here to be directed to the article by Schonau et al (2017).

November 2017

Click here to be directed to the article by Ordi-Ros et al (2017).

Click here to be directed to the article by Khanna et al (2017).


October 2017

Click here to be directed to the article by Elhai et al (2017).

Click here to be directed to the article by Huang et al (2017).