What Is New - Spondyloarthritis and Psoriatic Arthritis

Take a look at our 'What is new' highlights in spondyloarthritis and psoriatic arthritis!

November 2022

"Deep learning algorithms for magnetic resonance imaging of inflammatory sacroiliitis in axial spondyloarthritis"

Why WIN?

Deep learning segmentation is a subset of artificial intelligence (AI) machine learning, and it currently has wide applications in various areas of medical imaging analysis. A deep learning segmentation algorithm prototype was developed for detection of MRI sacroiliitis. Performance of the AI algorithm was similar to that of the radiologist, and superior to that of the rheumatologist.

Interactive question

Do you consider that artificial intelligence machine learning algorithms may be utilized for the diagnosis of SpA and the assessment of disease activity?

Share your response with us using the hashtag #WhatIsNew and tag us @EMEUNET

"Diagnostic evaluation of the sacroiliac joints for axial spondyloarthritis: should MRI replace radiography?"

Why WIN?

The diagnosis of axial SpA is strongly imaging based. The most recent EULAR Recommmendations for Imaging in SpA suggest conventional x-ray of the sacroiliac joints (SIJs) as the primary imaging modality in suspected cases of axSpA. Recent evidence suggest clear superiority of MRI over x-ray also for the assessment of structural changes of the SIJs. This lead to the viewpoint just published in ARD. This should trigger a discussion within the community taking costs, access in different settings/geographical regions, radioation exposure and ability for early diagnosis of axSpA into account.

Interactive question

What is your preferred first imaging modality in patients with suspicion of axSpA?

a) x-ray of the SIJs

b) MRI of the SIJs

c) None of the above. Please explain in the comments

Share your response with us using the hashtag #WhatIsNew and tag us @EMEUNET

October 2022

"Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling"

Why WIN?

The ability to identify patients with psoriasis who are at a high risk of developing PsA is an important goal for clinical research, as this would allow early intervention to reduce the impact of PsA and ultimately lead to preventative treatments.

Interactive question

Do you consider that future research on PsA susceptibility in patients with psoriasis should combine clinical data and genetics with longitudinal prospective studies in patients with clinically well-defined PsC before treatment with biologic drugs?

Share your response with us using the hashtag #WhatIsNew and tag us @EMEUNET

 

"Recapture and retreatment rates with ixekizumab after withdrawal of therapy in patients with axial spondyloarthritis: results at week 104 from a randomised placebo-controlled withdrawal study"

Why WIN?

Treating to target (T2T) is a well established concept in inflammatory rheumatic disease and is recommended also in SpA. But how to proceed when remission as the desired goal of treatment is achieved? In other words: how to treat from target (TFT)? Check out the recent publication on the flare rates after treatment withdrawal of IL-17Ai in axSpA and recapture rates after re-introducing treatment.

Interactive question

Is the glass half- full or half empty? How is your perspective: if you would be a patient, would you stop an effective drug if the chances of having a disease flare needing re-treatment is approx. 50%? YES or NO?

Important insights from COAST-Y: high proportion recaptured low disease activity after re-introduction of IL-17A inhibition!

Let us hear your perspectives! Share your response with us using the hashtag #WhatIsNew and tag us @EMEUNET

September 2022

"Elevated Th17 cells are associated with cardiovascular complications in ankylosing spondylitis"

Why WIN?

Patients with AS exhibit increased risk of cardiovascular diseases (CVD) compared with the general population, making the long-term management a great challenge. The study aimed to examine the levels of peripheral lymphocyte and CD4+ T-cells in AS-CVD, and explore their correlations with the presence of CVD, suggesting that elevated Th17 cells may correlate with the development of CVD in AS.

Interactive question

Do you consider that the elevation in Th17 cells could be a predictive risk for developing cardiovascular diseases in AS patients and that Th17 cells and Th17-derived cytokines can be potential therapeutic targets of AS-CVD?

Share your response with us using the hashtag #WhatIsNew and tag us @EMEUNET

 

"Isolated axial disease in psoriatic arthritis and ankylosing spondylitis with psoriasis"

Why WIN?

Under the umbrella term of Spondyloarthritis (SpA) different diseases with overlapping features are subsumed, while axial Spondyloathritis (axSpA) and Psoriatic Arthritis (PsA) are its primary representatives. The overlap between those diseases is obvoius and currently it is a matter of debate and a 'hot topic' of SpA research if axSpA and axial disease of PsA (axial PsA) are different phenotypes of the same disease or different diseases with great similarities.

Interactive question

Are axPsA and axSpA with Psoriasis the same disease just looked at from different perspectives?

Let us hear your perspectives! Share your response with us using the hashtag #WhatIsNew and tag us @EMEUNET

 

April 2022

March 2022

February 2022

December 2021

November 2021

October 2021

Aug 2021

Jan 2021

December 2020

November 2020

October 2020

Sep 2020

February 2020

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December 2019

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Sep 2019

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July 2019

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April 2019

March 2019

February 2019

Jan 2019

December 2018

Nov 2018

October 2018

Sep 2018

Click here  to be directed to the article by Kuperus et al (2018).

Click here  to be directed to the article by Baricza et al (2018).

Aug 2018

Click here  to be directed to the article by de Winter et al (2018).

Click here  to be directed to the article by Alivernini et al (2018).

July 2018

Click here  to be directed to the article by Tinazzi et al (2018).

Click here  to be directed to the article by Puchner et al (2018).

June 2018

Click here  to be directed to the article by Zabotti et al (2018).