What Is New - Osteoarthritis

Take a look at our 'What is new' highlights in osteoarthritis!

February 2023

"Potential effects of teriparatide (PTH (1-34)) on osteoarthritis: a systematic review"

Why WIN?

Teriparatide could be a possible disease-modifying OA drug through the drug repurposing process.

Interactive question

Could you give some other examples of drug repurposing in rheumatology? Yes/No

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January 2023

"A systematic review of the sex differences in risk factors for knee osteoarthritis"

Why WIN?

This review presents the first high-quality evidence regarding gender differences and risk for osteoarthritis development

Interactive question

Is a gender-targeted approach to OA prevention required in routine clinical practice? Yes/No

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December 2022

"Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores"

Why WIN?

Polygenic risk scores (PRS) have been utilized as a tool to stratify individuals into different risk groups and they are currently explored for several diseases

Interactive question

Can polygenic risk scores be useful in OA prevention in the near future? Yes/No

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October 2022

"Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative"

Why WIN?

There is strong evidence that nutritional regimens for weight loss are effective treatment for knee osteoarthritis (KOA). A diet rich in whole grains might be further beneficial for preventing KOA in susceptible people

Interactive question

Do you recommend specific diet regimens for patients with knee osteoarthritis? If yes, feel free to share your expertise? Yes/No

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September 2022

"Serum biomarkers in prednisolone treated hand osteoarthritis patients"

Why WIN?

Hand osteoarthritis is a highly prevalent condition causing disability that has largely been ignored. This study analyzed biomarkers modulated by prednisolone treatment in patients with hand OA. Their ability to predict response to prednisolone was also assessed.

Interactive question

Do you use systemic prednisolone in the management of hand osteoarthritis?

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May 2022

"Osteoarthritis endotype discovery via clustering of biochemical marker data"

Why WINS?

This study identified three endotypes associated with three distinct osteoarthritis phenotypes based on a large set of biomarkers in a cohort of patients with tibiofemoral osteoarthritis.

Interactive question

Do you believe that patient stratification using biomarkers is a useful strategy for future clinical trials aiming at identifying effective treatments for patients with osteoarthritis?

yes/no

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